亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Musculoskeletal disease in acromegaly – a population-based registry study

肢端肥大症 医学 内科学 内分泌学 疾病 人口 生长激素 激素 环境卫生
作者
Christian Rosendal,Mai Christiansen Arlien-Søborg,Eigil Husted Nielsen,Claus Larsen Feltoft,Åse Krogh Rasmussen,Marianne Andersen,Jens Otto Lunde Jørgensen,Jakob Dal
出处
期刊:European journal of endocrinology [Bioscientifica]
标识
DOI:10.1093/ejendo/lvaf047
摘要

Abstract Objective Acromegaly is associated with multiple musculoskeletal complications that affect quality of life and work ability. We aimed to examine the risk of osteoarthritis, musculoskeletal surgery (incl. joint replacement), osteoporosis, fractures and analgesic consumption in Danish acromegaly patients. Design National, registry-based cohort study. Methods All validated incident and prevalent cases of acromegaly in the period 1977-2021 (n=844) were included and matched 1:100 with healthy controls. Outcomes were identified using diagnosis, surgical procedure and medication codes, and analyzed using Cox regression and Kaplan-Meier plots. Results Patients were at significantly increased risk of osteoarthritis of the shoulder (HR: 5.25 [3.05; 9.06]), hip (HR: 3.15 [2.57; 3.87]) and knee (HR: 2.25 [1.85; 2.72]), and medically treated osteoporosis (HR: 2.13 [1.64; 2.78]) even before acromegaly diagnosis. The risk of joint replacement surgery of the shoulder (HR: 4.60 [2.57; 8.25]), hip (HR: 3.32 [2.67; 4.12]) and knee (HR: 2.52 [1.89; 3.36]) was increased in acromegaly patients, as was the risk of being prescribed weak analgesics (HR: 1.22 [1.04; 1.44]) or opioids (HR: 1.58 [1.38; 1.82]). Surgical complications (HR: 2.19 [1.59; 3.03]) and repeat hip surgery (HR: 3.64 [2.09; 6.34]) also exhibited increased risk in patients. Conclusion In acromegaly, severe osteoarthritis involving multiple joints develops even before acromegaly diagnosis and continues to progress over time after acromegaly treatment. Furthermore, acromegaly imposes an increased risk of medically treated osteoporosis, musculoskeletal surgery - particularly joint replacement surgery -, surgical complications and necessity of analgesic medication. Our findings warrant further research into the management of musculoskeletal disease in acromegaly.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
111完成签到,获得积分10
1秒前
JamesPei应助苹果秋灵采纳,获得10
6秒前
8秒前
9秒前
11秒前
12秒前
TongMan完成签到,获得积分10
13秒前
疯度发布了新的文献求助10
13秒前
苹果秋灵完成签到,获得积分10
15秒前
15秒前
跳跃的香完成签到 ,获得积分10
15秒前
桐桐应助苗条啤酒采纳,获得10
16秒前
白丁香发布了新的文献求助30
16秒前
NexusExplorer应助疯度采纳,获得10
19秒前
20秒前
苹果秋灵发布了新的文献求助10
21秒前
杏子尽欢冰完成签到,获得积分10
28秒前
breeze完成签到,获得积分10
28秒前
健康的修洁完成签到 ,获得积分10
30秒前
李大刚完成签到 ,获得积分10
30秒前
30秒前
35秒前
流白完成签到 ,获得积分10
43秒前
44秒前
笑点低涟妖完成签到 ,获得积分10
46秒前
50秒前
JamesPei应助活力的如冬采纳,获得10
51秒前
在水一方完成签到 ,获得积分10
53秒前
55秒前
墨绿色的丑梨完成签到,获得积分10
1分钟前
1分钟前
活力的如冬完成签到,获得积分10
1分钟前
Boooo完成签到 ,获得积分10
1分钟前
1分钟前
痴情的明辉完成签到 ,获得积分10
1分钟前
syl4316完成签到 ,获得积分10
1分钟前
爆米花应助LLQ采纳,获得10
1分钟前
1分钟前
1分钟前
张小仙发布了新的文献求助10
1分钟前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Typology of Conditional Constructions 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3571115
求助须知:如何正确求助?哪些是违规求助? 3141818
关于积分的说明 9444414
捐赠科研通 2843171
什么是DOI,文献DOI怎么找? 1562737
邀请新用户注册赠送积分活动 731218
科研通“疑难数据库(出版商)”最低求助积分说明 718468