自噬
PI3K/AKT/mTOR通路
DNA
细胞生物学
四面体
纳米结构
化学
材料科学
细胞凋亡
纳米技术
信号转导
生物
结晶学
生物化学
作者
Sirong Shi,Shiyu Lin,Yong Li,Tao Zhang,Xiaoru Shao,Taoran Tian,Tengfei Zhou,Qianshun Li,Yunfeng Lin
摘要
Tetrahedral DNA nanostructures (TDNs) have gathered great attention and are being widely used in biomedicine. We demonstrated that autophagy increased after exposure to TDNs (250 nM) along with the up-regulation of several autophagy-related genes and proteins. TDNs enhanced cell autophagy through the PI3K/AKT/mTOR signaling pathway.
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