粘合连接
钙粘蛋白
生物
接触抑制
运动性
细胞生物学
癌细胞
细胞粘附
表型
粘附
癌症
癌症研究
细胞生长
细胞
遗传学
基因
化学
有机化学
作者
Alisha M. Mendonsa,Tae-Young Na,Barry M. Gumbiner
出处
期刊:Oncogene
[Springer Nature]
日期:2018-05-21
卷期号:37 (35): 4769-4780
被引量:273
标识
DOI:10.1038/s41388-018-0304-2
摘要
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.
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