生物
蛋白质细菌
失调
专性厌氧菌
兼性
肠道菌群
使负有责任或义务
微生物学
细菌
无氧运动
免疫学
生理学
遗传学
生态学
16S核糖体RNA
作者
Yael Litvak,Mariana X. Byndloss,Renée M. Tsolis,Andreas J. Bäumler
标识
DOI:10.1016/j.mib.2017.07.003
摘要
A balanced gut microbiota is important for health, but the mechanisms maintaining homeostasis are incompletely understood. Anaerobiosis of the healthy colon drives the composition of the gut microbiota towards a dominance of obligate anaerobes, while dysbiosis is often associated with a sustained increase in the abundance of facultative anaerobic Proteobacteria, indicative of a disruption in anaerobiosis. The colonic epithelium is hypoxic, but intestinal inflammation or antibiotic treatment increases epithelial oxygenation in the colon, thereby disrupting anaerobiosis to drive a dysbiotic expansion of facultative anaerobic Proteobacteria through aerobic respiration. These observations suggest a dysbiotic expansion of Proteobacteria is a potential diagnostic microbial signature of epithelial dysfunction, a hypothesis that could spawn novel preventative or therapeutic strategies for a broad spectrum of human diseases.
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