The Subarachnoid Hemorrhage Early Brain Edema Score Predicts Delayed Cerebral Ischemia and Clinical Outcomes

医学 蛛网膜下腔出血 队列 代理终结点 格拉斯哥结局量表 内科学 缺血 心脏病学 脑水肿 试验预测值 放射科 格拉斯哥昏迷指数 外科
作者
Sung‐Ho Ahn,Jude Savarraj,Mubashir Pervez,Wesley Jones,Jin Park,Sang‐Beom Jeon,Sun U. Kwon,Tiffany Chang,Kiwon Lee,Dong Kim,Arthur L. Day,H. Alex Choi
出处
期刊:Neurosurgery [Lippincott Williams & Wilkins]
卷期号:83 (1): 137-145 被引量:165
标识
DOI:10.1093/neuros/nyx364
摘要

Abstract BACKGROUND Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an important determinant of clinical outcomes. However, a major hindrance to studies of EBI is the lack of radiographic surrogate marker. OBJECTIVE To propose a scoring system based on early changes in clinically obtained computed tomography (CT), called the Subarachnoid hemorrhage Early Brain Edema Score (SEBES). METHODS Patients with spontaneous aneurysmal SAH and a CT within 24 h of ictus were included. We defined SEBES as a scale of 0 to 4 points according to the (1) absence of visible sulci caused by effacement of sulci or (2) absence of visible sulci with disruption of the gray–white matter junction at 2 predetermined levels in each hemisphere. Prognostic value of the SEBES grade for the prediction of delayed cerebral ischemia (DCI) and unfavorable outcomes was assessed. A separate cohort of patients was used as a validation cohort. RESULTS Of the 164 subjects in our study, high-grade SEBES (3 or 4 points) was identified in 48 patients (29.3%). CT interobserver reliability of SEBES grades was high with a Kappa value of 0.89. After adjusting for covariables, SEBES was identified as an independent predictor of DCI (OR = 2.24, 95% CI: 1.58–3.17) and unfavorable outcome (OR = 3.45, 95% CI: 1.95–6.07). In our validation cohort, 84 subjects showed similar predictive power of SEBES for a prediction of DCI and unfavorable long-term outcome. CONCLUSION SEBES may be a surrogate marker of EBI and predicts DCI and clinical outcomes after SAH.
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