Systematic review with meta‐analysis: post‐infectious functional dyspepsia

Summary Background The prevalence of functional dyspepsia ( FD ) following infectious gastroenteritis has not been systematically reviewed. Aim To conduct a systematic review and calculate the summary odds ratio ( OR ) for the development of FD following infectious gastroenteritis, as compared to a control population. Methods Published studies in PubMed, Em BASE , and Cochrane Database and abstracts from standard sources were screened for eligible studies. Data from studies meeting inclusion criteria were pooled for meta‐analysis. Results Nineteen studies were eligible for inclusion. The mean prevalence of FD following acute gastroenteritis ( AGE ) was 9.55% ( FD , n = 909; AGE , n = 9517) in adult populations. The summary OR for the development of post‐infectious FD was 2.54 (95% CI = 1.76–3.65) at more than 6 months after AGE , as compared to the prevalence in controls within the same population. This is compared with the summary OR (3.51; 95% CI = 2.05–6.00) for the development of post‐infectious irritable bowel syndrome ( IBS ) in the same population at more than 6 months after AGE . There was significant statistical heterogeneity with an I 2 of 72.8% for the summary OR of post‐infectious FD . Several pathogens, including Salmonella spp., Escherichia coli O157 , Campylobacter jejuni , Giardia lamblia and Norovirus have been shown to be associated with post‐infectious FD symptoms. Conclusions Infectious gastroenteritis is associated with an increased risk for subsequent dyspepsia as well as for irritable bowel syndrome. Post‐infectious FD and post‐infectious irritable bowel syndrome may represent different aspects of the same pathophysiology. Further studies will be needed to determine this.