双酚A
双酚
双酚S
色谱法
尿
化学
检出限
四溴双酚A
内分泌干扰物
环境化学
固相萃取
内分泌系统
有机化学
生物化学
阻燃剂
激素
环氧树脂
作者
Yunjia Yang,Jian Guan,Jie Yin,Bing Shao,Hong Li
出处
期刊:Chemosphere
[Elsevier]
日期:2014-06-05
卷期号:112: 481-486
被引量:209
标识
DOI:10.1016/j.chemosphere.2014.05.004
摘要
The use of bisphenol A (BPA) has been restricted in many countries because of its potential health effects. As a result of these restrictions, a group of bisphenol analogues that are structurally similar to BPA have been developed as the alternatives for industrial applications. However, latest researches indicated that these chemicals have similar endocrine-disrupting effects as BPA in humans. Moreover, only a limited number of studies have attempted to monitor the exposure level in humans of other bisphenol analogues. In the present study, the concentrations of seven bisphenols, including bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), BPA, bisphenol AF (BPAF), tetrachlorobisphenol A (TCBPA) and tetrabromobisphenol A (TBBPA), in human urine samples were measured by liquid chromatography coupled to mass spectrometry (LC–MS/MS) following the enzymatic hydrolysis of glucuronidase/arylsulfatase and liquid–liquid extraction (LLE). Under the optimised conditions, high recoveries (81.6–116.8%) were obtained for all the analytes, and the relative standard deviations (RSD, %) were less than 16.4% (n = 6). The isotopic internal standard calibration curves for each of the target compounds exhibited excellent linearity (r2 > 0.99) and the limit of quantification (LOQ) for the analytes in urine ranged from 0.024 to 0.310 ng mL−1. The method was applied to investigate the urinary levels of these seven bisphenols in a cohort of residents living near a BPAF manufacturing plant in south China. BPS, BPF, BPA and BPAF were detected in urine samples at concentrations ranging from
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