内分泌系统
内分泌干扰物
激素
2型糖尿病
人类健康
生物
生物信息学
医学
糖尿病
内分泌学
环境卫生
作者
Cristina Casals‐Casas,Béatrice Desvergne
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2011-03-17
卷期号:73 (1): 135-162
被引量:725
标识
DOI:10.1146/annurev-physiol-012110-142200
摘要
Synthetic chemicals currently used in a variety of industrial and agricultural applications are leading to widespread contamination of the environment. Even though the intended uses of pesticides, plasticizers, antimicrobials, and flame retardants are beneficial, effects on human health are a global concern. These so-called endocrine-disrupting chemicals (EDCs) can disrupt hormonal balance and result in developmental and reproductive abnormalities. New in vitro, in vivo, and epidemiological studies link human EDC exposure with obesity, metabolic syndrome, and type 2 diabetes. Here we review the main chemical compounds that may contribute to metabolic disruption. We then present their demonstrated or suggested mechanisms of action with respect to nuclear receptor signaling. Finally, we discuss the difficulties of fairly assessing the risks linked to EDC exposure, including developmental exposure, problems of high- and low-dose exposure, and the complexity of current chemical environments.
科研通智能强力驱动
Strongly Powered by AbleSci AI