活性氧
细胞毒性
阿扎胞苷
氧化应激
组蛋白脱乙酰基酶
超氧化物
表观遗传学
甲基转移酶
化学
组蛋白脱乙酰酶抑制剂
过氧化氢
细胞凋亡
长时程增强
甲基化
组蛋白
DNA甲基化
生物化学
体外
DNA
酶
基因表达
受体
基因
作者
Shan Gao,Aaron K. Mobley,Claudia P. Miller,Jessica Boklan,Joya Chandra
标识
DOI:10.1016/j.leukres.2007.09.007
摘要
Epigenetic modifiers are currently in clinical use for various tumor types. Recently, numerous studies supporting the combination of histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors have emerged, encouraging early clinical trials of these agents together. Here we show that MS-275, an HDACi, and 5-azacytidine, a methyltransferase inhibitor, display synergistic cytotoxicity and apoptosis in AML and ALL cells. Intracellular production of reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, is a novel marker for this synergism in ALL cells. These data suggest that assessment of oxidative stress can serve as a marker of the concerted action of MS-275 and 5-azacytidine.
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