New Derivatives of VAPOL and VANOL: Structurally Distinct Vaulted Chiral Ligands and Brønsted Acid Catalysts

Lean and efficient multi-gram scale syntheses of a number of new derivatives of VAPOL and VANOL are described. These are structurally novel chiral ligands and Brønsted acid catalysts, and could provide singular profiles for reactivity and asymmetric inductions in catalysis.