两亲性
小泡
乙二醇
材料科学
脂质体
药物输送
生物传感器
共聚物
化学
化学工程
聚合物
膜
纳米技术
有机化学
生物化学
工程类
作者
Alessandro Napoli,Massimiliano Valentini,Nicola Tirelli,Martin Müller,Jeffrey A. Hubbell
出处
期刊:Nature Materials
[Springer Nature]
日期:2004-02-15
卷期号:3 (3): 183-189
被引量:830
摘要
Vesicles formed in water by synthetic macro-amphiphiles have attracted much attention as nanocontainers having properties that extend the physical and chemical limits of liposomes. We sought to develop ABA block copolymeric amphiphiles that self-assemble into unilamellar vesicles that can be further oxidatively destabilized. We selected poly(ethylene glycol) (PEG) as the hydrophilic A blocks, owing to its resistance to protein adsorption and low toxicity. As hydrophobic B blocks, we selected poly(propylene sulphide) (PPS), owing to its extreme hydrophobicity, its low glass-transition temperature, and most importantly its oxidative conversion from a hydrophobe to a hydrophile, poly(propylene sulphoxide) and ultimately poly(propylene sulphone). This is the first example of the use of oxidative conversions to destabilize such carriers. This new class of oxidation-responsive polymeric vesicles may find applications as nanocontainers in drug delivery, biosensing and biodetection.
科研通智能强力驱动
Strongly Powered by AbleSci AI