Interleukin-17 in systemic lupus erythematosus: A comprehensive review

免疫学 医学 类风湿性关节炎 狼疮性肾炎 强直性脊柱炎 银屑病 发病机制 自身抗体 白细胞介素17 系统性红斑狼疮 自身免疫性疾病 自身免疫 趋化因子 免疫系统 疾病 关节炎 抗体 内科学
作者
Duo Li,Bin Guo,Haijing Wu,Lina Tan,Christopher Chang,Qianjin Lu
出处
期刊:Autoimmunity [Informa]
卷期号:48 (6): 353-361 被引量:85
标识
DOI:10.3109/08916934.2015.1037441
摘要

Systemic lupus erythematosus (SLE) is a complicated autoimmune disease of multifactorial pathoaetiology. One of the most serious manifestations is lupus nephritis. The pathogenesis of SLE has not been well elucidated, but it has been reported that interleukin-17 (IL-17) and Th17 cells play important roles in the pathogenesis of SLE. IL-17A, a member of IL-17 family, amplifies the immune response by inducing the local production of chemokines and cytokines, recruiting neutrophils and monocytes, augmenting the production of autoantibodies, and aggravating the inflammation and damage of target organs such as the kidney in SLE. In recent years, several IL-17A pathway inhibitors have advanced into clinical trials, including the anti-IL-17A monoclonal antibody and the anti-17RA monoclonal antibody. Several agents have shown great success in Phase II trials in multiple autoimmune diseases such as psoriasis, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, and non-infectious uveitis, which has sparked the urgent need of anti-IL-17A as innovative therapeutic option in controlling disease activity of moderate-to-severe SLE. Here, we review and summarize current progress in IL-17A and SLE from in vitro studies, human expression studies, and animal models, providing novel insight into its therapeutic potential.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
weiwei发布了新的文献求助10
1秒前
poli发布了新的文献求助10
2秒前
诚心尔琴发布了新的文献求助10
3秒前
3秒前
fgh完成签到,获得积分20
3秒前
CipherSage应助科研通管家采纳,获得10
4秒前
CAOHOU应助科研通管家采纳,获得10
4秒前
NexusExplorer应助科研通管家采纳,获得10
4秒前
SYLH应助科研通管家采纳,获得10
4秒前
英俊的铭应助科研通管家采纳,获得10
4秒前
Akim应助科研通管家采纳,获得10
4秒前
SYLH应助科研通管家采纳,获得10
4秒前
4秒前
CodeCraft应助科研通管家采纳,获得10
5秒前
乐乐应助科研通管家采纳,获得10
5秒前
爱听歌芝麻完成签到,获得积分10
5秒前
FashionBoy应助科研通管家采纳,获得10
5秒前
峥2发布了新的文献求助10
5秒前
上官若男应助科研通管家采纳,获得10
5秒前
musejie应助科研通管家采纳,获得10
5秒前
丘比特应助科研通管家采纳,获得10
5秒前
李爱国应助科研通管家采纳,获得10
5秒前
5秒前
ding应助科研通管家采纳,获得10
5秒前
1111应助科研通管家采纳,获得20
5秒前
6秒前
彭于彦祖应助科研通管家采纳,获得30
6秒前
wanci应助科研通管家采纳,获得10
6秒前
田様应助科研通管家采纳,获得10
6秒前
6秒前
Akim应助ll采纳,获得10
6秒前
科研通AI2S应助科研通管家采纳,获得10
6秒前
我是老大应助ll采纳,获得10
6秒前
pcr163应助科研通管家采纳,获得50
6秒前
传奇3应助科研通管家采纳,获得10
6秒前
7秒前
7秒前
7秒前
搜集达人应助科研通管家采纳,获得10
7秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988786
求助须知:如何正确求助?哪些是违规求助? 3531116
关于积分的说明 11252493
捐赠科研通 3269766
什么是DOI,文献DOI怎么找? 1804771
邀请新用户注册赠送积分活动 881870
科研通“疑难数据库(出版商)”最低求助积分说明 809021