免疫学
医学
类风湿性关节炎
狼疮性肾炎
强直性脊柱炎
银屑病
发病机制
自身抗体
白细胞介素17
系统性红斑狼疮
自身免疫性疾病
自身免疫
趋化因子
免疫系统
疾病
关节炎
抗体
内科学
作者
Duo Li,Bin Guo,Haijing Wu,Lina Tan,Christopher Chang,Qianjin Lu
出处
期刊:Autoimmunity
[Informa]
日期:2015-04-20
卷期号:48 (6): 353-361
被引量:85
标识
DOI:10.3109/08916934.2015.1037441
摘要
Systemic lupus erythematosus (SLE) is a complicated autoimmune disease of multifactorial pathoaetiology. One of the most serious manifestations is lupus nephritis. The pathogenesis of SLE has not been well elucidated, but it has been reported that interleukin-17 (IL-17) and Th17 cells play important roles in the pathogenesis of SLE. IL-17A, a member of IL-17 family, amplifies the immune response by inducing the local production of chemokines and cytokines, recruiting neutrophils and monocytes, augmenting the production of autoantibodies, and aggravating the inflammation and damage of target organs such as the kidney in SLE. In recent years, several IL-17A pathway inhibitors have advanced into clinical trials, including the anti-IL-17A monoclonal antibody and the anti-17RA monoclonal antibody. Several agents have shown great success in Phase II trials in multiple autoimmune diseases such as psoriasis, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, and non-infectious uveitis, which has sparked the urgent need of anti-IL-17A as innovative therapeutic option in controlling disease activity of moderate-to-severe SLE. Here, we review and summarize current progress in IL-17A and SLE from in vitro studies, human expression studies, and animal models, providing novel insight into its therapeutic potential.
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