醛糖还原酶
多元醇途径
医学
糖尿病
愤怒(情绪)
冠状动脉疾病
糖基化
糖尿病性心肌病
内科学
心脏病学
背景(考古学)
心肌梗塞
疾病
内分泌学
心肌病
心力衰竭
生物
神经科学
古生物学
作者
Minoru Kaneko,Loredana Bucciarelli,Yuying C. Hwang,Larisee Lee,Shi Fang Yan,Ann Marie Schmidt,Ravichandran Ramasamy
标识
DOI:10.1196/annals.1333.081
摘要
Cardiovascular disease represents the major cause of morbidity and mortality in patients with diabetes mellitus. The impact of cardiac disease includes increased sensitivity of diabetic myocardium to ischemic episodes and diabetic cardiomyopathy, manifested as a subnormal functional response of the diabetic heart independent of coronary artery disease. In this context, we were to our knowledge the first to demonstrate that diabetes increases glucose flux via the first and key enzyme, aldose reductase, of the polyol pathway, resulting in impaired glycolysis under normoxic and ischemic conditions in diabetic myocardium. Our laboratory has been investigating the role of the polyol pathway in mediating myocardial ischemic injury in diabetics. Furthermore, the influence of the aldose reductase pathway in facilitating generation of key potent glycating compounds has led us to investigate the impact of advanced glycation end products (AGEs) in myocardial ischemic injury in diabetics. The potent impact of increased flux via the aldose reductase pathway and the increased AGE interactions with its receptor (RAGE) resulting in cardiac dysfunction will be discussed in this chapter.
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