前药
放射治疗
缺氧(环境)
坏死
医学
遗传增强
化疗
癌症
转录因子
癌症研究
肿瘤缺氧
癌症治疗
缺氧诱导因子
生物
内科学
药理学
基因
化学
生物化学
氧气
有机化学
作者
J. Martin Brown,William R. Wilson
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2004-06-01
卷期号:4 (6): 437-447
被引量:2520
摘要
Solid tumours contain regions at very low oxygen concentrations (hypoxia), often surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both radiotherapy and chemotherapy. However, the existence of hypoxia and necrosis also provides an opportunity for tumour-selective therapy, including prodrugs activated by hypoxia, hypoxia-specific gene therapy, targeting the hypoxia-inducible factor 1 transcription factor, and recombinant anaerobic bacteria. These strategies could turn what is now an impediment into a significant advantage for cancer therapy.
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