Historical aspects of glutathione and cancer chemotherapy

This presentation sets in historical context the impact of glutathione and its metabolism upon the efficacy of several anticancer drugs. The basic biochemistry of the tripeptide is reviewed briefly, highlighting its role in oxido-reduction and in the γ-glutamyl cycle. The ability of selective modulators of glutathione metabolism, such as buthionine sulfoximine, as adjuncts to chemotherapy is also discussed.