Shortened Telomeres in Families With a Propensity to Autism

端粒 先证者 自闭症谱系障碍 兄弟姐妹 自闭症 心理学 遗传学 医学 生物 发展心理学 基因 突变
作者
Charles A. Nelson,Kandice J. Varcin,Nicole K. Coman,Immaculata De Vivo,Helen Tager‐Flusberg
出处
期刊:Journal of the American Academy of Child and Adolescent Psychiatry [Elsevier]
卷期号:54 (7): 588-594 被引量:23
标识
DOI:10.1016/j.jaac.2015.04.006
摘要

Shortened telomeres have been linked to poorer health outcomes. Exposure to psychological stress is associated with accelerated telomere shortening, and a well-established body of evidence indicates that families with a child with autism spectrum disorder (ASD) experience heightened levels of psychological stress. Also, alterations in a number of biological processes implicated in telomere length dynamics (i.e., oxidative stress, DNA methylation) have been linked to ASD susceptibility. We examined whether families of children with ASD who have an infant show shortened telomeres.Saliva samples were collected from infants, their older sibling (proband), and parents in families with or without a child with ASD. Infants and their families were designated as high-risk for ASD (HRA; n = 86) or low-risk for ASD (LRA; n = 118) according to the older siblings' diagnostic status. We used the real-time polymerase chain reaction (PCR) telomere assay to determine relative average telomere length for each participant.HRA families demonstrated significantly shorter telomere length relative to LRA families. This effect was observed at the individual family member level, with infants, probands, and mothers in HRA families showing reduced relative telomere length compared to individuals in LRA families; although not significant, fathers of high-risk infants showed a similar pattern of decreased telomere length.Families of children with ASD who have an infant show shortened telomeres relative to families with no history of ASD. These results suggest that such "high-risk" families should be monitored for the physical and mental health consequences that are often associated with accelerated telomere shortening.
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