锌指
同源(生物学)
生物
基因
LIM域
转录因子
无名指区
分子生物学
造血
转录因子Sp1
锌
细胞生物学
化学
遗传学
基因表达
发起人
干细胞
有机化学
作者
Weiping Zhang,Jing Mi,Nan Li,Lili Sui,Tao Wan,Jia Zhang,Taoyong Chen,Xuetao Cao
标识
DOI:10.1006/bbrc.2001.4689
摘要
The C2H2 zinc finger protein family is one of the largest families of transcription factors. We identified a novel BTB/POZ zinc finger gene from human dendritic cells (DC), which encodes a 733-residue protein with a BTB/POZ domain at the N-terminal and 4 C2H2 zinc fingers at C-terminal. It was designated dendritic cell-derived BTB/POZ zinc finger (DPZF). DPZF protein shares closest homology to BCL-6, with the highest homology present in the BTB/POZ and zinc finger domains. Like BCL-6, DPZF gene is localized on chromosome 3. It is widely expressed in hematopoietic tissues, including DC, monocytes, B cells, and T cells. DPZF protein expression is detectable in lymphoid neoplasm with a molecular mass of 100 kD, especially in B lymphoma. These indicate that DPZF may be a transcription factor closely related to BCL-6, and may be involved in hematopoiesis, oncogenesis, and immune responses.
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