Cathelicidin can reverse intestinal fibrosis in models of colitis

which are associated with increased collagen expression: trinitrobenzene sulphonic acid (TNBS)-induced colitis and Salmonella-typhimurium-induced caecal inflammation. Administration of cathelicidin (via intracolonic enema or injection with lentiviral particles expressing the cathelicidin gene) in both of these mouse models was found to attenuate collagen synthesis and deposition. “In terms of cell culture,