硼酸化
化学
钯
芳基
卤化物
组合化学
配体(生物化学)
溶剂
催化作用
有机化学
生物化学
受体
烷基
作者
Pavel B. Dzhevakov,Maxim A. Topchiy,Daria A. Zharkova,Oleg S. Morozov,Andrey F. Asachenko,M.S. Nechaev
标识
DOI:10.1002/adsc.201500844
摘要
Abstract Solvent‐free protocols for Miyaura borylation and the one‐pot, two‐step homocoupling of aryl halides are reported for the first time. Bis(dibenzylideneacetone)palladium(0) [Pd(dba) 2 ] is an optimal source of palladium for Miyaura borylation, while for one‐pot two‐step homocoupling palladium(II) acetate [Pd(OAc) 2 ] gives highest yields. Aryl bromides are coupled most efficiently using the DPEphos ligand. Chlorides are coupled using XPhos. The developed protocols are robust, versatile and easily reproducible on a large scale. magnified image
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