Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis

The performance of an interferometric sensing device based on integrated Bimodal Waveguides (BiMW) is demonstrated.Fabricated using standard silicon technology, the sensors can achieve a detection limit of 2.5•10 -7 RIU for homogeneous sensing, rendering in a high sensitive device.The applicability of the bimodal waveguide interferometers as label-free biosensors has been demonstrated by the real-time detection of the biomolecular interaction of BSA and anti-BSA .Due to their simplicity, the devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing as a powerful instrument for biochemical analysis.