Tagging along: A DNA detection method has been developed that relies on the interfacial assembly of gold nanoparticles. The fluorous-tag-driven formation of nanoparticle networks (see scheme) at the gas/liquid, liquid/liquid, or solid/liquid interface is such that a single type of assembly architecture is suitable for an array of detection formats. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.