• Pipeline leakage risk assessment. • CO2 versus other pipeline type risk comparison. • Risk developed per mile of pipeline. • Risks assessment for CO2 storage via CO2-EOR. • Likelihood of leakage developed based on actual incident data. • Consequences developed in dollars using OSHA data. • Risk calculated in dollars for hypothetical pipelines in the midcontinent United States. • The methods and results allow potential project developers to estimate pipeline risks associated with their projects. A comprehensive quantitative risk assessment for the construction and operation of CO 2 transportation networks considered for the Midcontinent United States was conducted. The results showed risks associated with CO 2 pipelines were significantly less than those of other pipeline types. The assessment used four conceptual pipelines of different lengths to discuss risks operators may see. The assessment evaluated the risk associated with construction and operation using data from the US Occupational Safety Health Administration to determine the risk of injury or death for pipeline workers and data from the US Pipeline and Hazardous Materials Safety Administration for CO 2 , natural gas distribution, natural gas transmission/gathering, and non-CO 2 hazardous liquid pipelines to develop quantitative likelihood and severity values leading to risk values. The data for the assessment covered incidents from 2010 to 2017 for CO 2 pipelines. The average risk for construction and 30 years of operation for four CO 2 pipeline configurations ranging between 79 and 1,546 miles in length was found. The construction and operational risk averaged between $1,400,521 (approximately $0.02/tonne of CO 2 ) for the shorter pipeline (79 miles) and $27,481,939 (approximately $0.10/tonne of CO 2 ) for a longer pipeline (1,546 miles). The largest risks of fatality for CO 2 pipelines comes from vehicle transport. The largest operational risk to the pipeline was due to leakage. Public pipeline opposition is also a significant risk; it was not quantified but is addressed.