替加环素
粘菌素
质粒
多重耐药
微生物学
生物
MCR-1型
多粘菌素
抗生素
耐碳青霉烯类肠杆菌科
抗药性
抗生素耐药性
肠杆菌科
基因
遗传学
大肠杆菌
作者
Liang Wang,Yao Wang,Xiaotong Jiang,Gong Xiaowei,Yang Wang,Zhangqi Shen
标识
DOI:10.1016/j.ijantimicag.2022.106619
摘要
Carbapenems, tigecycline and colistin are three important antimicrobial agents for the treatment of clinical infections caused by multidrug-resistant Enterobacteriaceae. Here we characterised the formation of hybrid plasmids containing mcr-8 and bla NDM-1 or tmexCD1-toprJ1 that could confer resistance to colistin and carbapenems or tigecycline. More specifically, these clinically important genes could be co-transferred through IS 26 - and ltrA -mediated plasmid fusion to clinical isolates during conjugation under single drug (colistin) selection, following which the recipient strains became carbapenem- or tigecycline-resistant. The transferability and stability of these hybrid multidrug resistance (MDR) plasmids depend on the bacterial host and the presence of antibiotics. Further evolution and adaptation of these hybrid plasmids may facilitate their emergence and spread, which is of great concern for clinical therapy.
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