Gestational Trophoblastic Disease

Pathologic diagnosis of gestational trophoblastic disease (GTD)—hydatidiform moles and gestational trophoblastic neoplasms—underwent a major shift in the past decade from morphology-based recognition to precise molecular genetic classification of entities, which also allows for prognostic stratification of molar gestations. This article highlights these recent advances and their integration into the routine pathology practice. The traditional gross and histomorphologic features of each entity are also reviewed with special focus on differential diagnoses and their clinical implications.