Dressing blood-contacting devices with platelet membrane enables large-scale multifunctional biointerfacing

So far, cloaking materials with platelet membranes have been widely studied, mainly focused on covering nanosized materials but rarely forwarded to dressing large-scale materials. Herein, a platelet-membrane coating (PMC) constructed on the surface of a macroscopic device is reported, driven by the spontaneous fusion of platelet-membrane vesicles (PMVs) with a negatively charged superhydrophilic surface. The coating contains not only phospholipids but also a variety of functional proteins of the platelet membrane, which is a further leap compared with surface-modification strategies of imitating cell-membrane structure with inert synthetic amphiphilic molecules. The preservation of membrane proteins by dressing PMC endows the surface of macroscopic devices with bioactivity. The implantation of vascular stents covered with PMC demonstrates the potential to address the desired biointerface properties, such as thromboprotection and anti-inflammation, and promote re-endothelialization. Overall, dressing large-scale blood-contacting materials with PMC provides a multifunctional biointerface by naturally preserved membrane proteins.