A recognition strategy combining effective boron affinity technology and surface imprinting to prepare highly selective and easily recyclable polymer membrane for separation of drug molecule

Cellulose acetate membrane (CAM) has become one of the most widely used membrane materials by virtue of stability and hydrophilicity. In this work, to achieve the aim of selective recognition and separation of drug molecule shikimic acid (SA), an effective recognition tactics was proposed by combining boron affinity technology with surface imprinting strategy based on cellulose acetate membrane with low price and biocompatibility. The supporting CAM material was prepared through the phase inversion technique by continuous adjustment of different factors including solvent type and kinds of pore-forming agents, and the optimal CAM with multistage structure and highly porosity was applied for the imprinting of SA. Then the imprinted polymer membrane (MIPs-CAM) was developed via boron affinity surface imprinting polymerization. Various methods (FT-IR, UV-vis, SEM, XPS, AFM and TGA) were used to characterize the structure, morphology, elemental composition, surface roughness and thermal property of the obtained membrane. The as-prepared MIPs-CAM showed homogeneous and abundant imprinted layer, good thermal stability. The batch adsorption results showed that the MIPs-CAM had fast adsorption kinetics, specific recognition ability, and the adsorption capacity could obtain 63.598 mg g-1, which was two times higher than that of non-imprinted membrane (NIPs-CAM). The adsorption isotherms conformed to the Langmuir isotherm and the adsorption processes were spontaneous and endothermic. Additionally, the adsorption capacity of MIPs-CAM still reached 85% of the initial result after five cycles. The experimental results revealed that the molecularly imprinted membrane possessed the advantages of high selectivity and easy recovery compared with the traditional molecular imprinted polymers for SA separation. These results indicate that boron affinity MIPs-CAM with high performance will provide a promising platform for the separation and purification of other cis-diol drug molecules from environmental resources.