医学
偏头痛
降钙素基因相关肽
慢性偏头痛
叙述性评论
药品
人口
偏头痛治疗
重症监护医学
生物信息学
药理学
内科学
受体
神经肽
生物
环境卫生
作者
Enrico Bentivegna,Michelangelo Luciani,Valeria Ferrari,Silvia Galastri,Francesco Baldari,Francesco Scarso,Piera Amoriello Lamberti,Paolo Martelletti
标识
DOI:10.1080/14656566.2022.2102420
摘要
Migraine occupies the first position regarding the disability caused in female working population (15-49 years). Research in the field of prophylaxis in this pathology has made enormous strides in recent years.In this narrative review, we retrace the most important scientific evidence regarding recently approved and emerging drugs for the prophylactic treatment of migraine. The purpose of this article is in fact to evaluate currently approved or emerging pharmacological agents for migraine prophylaxis. This review is based on the literature published in the peer review journal obtained through PubMed, Cochrane library, Clinicaltrials.gov, and US FDA.Monoclonal antibodies (mAbs) that target the calcitonin gene-related peptide signaling pathway (CGRP) have marked an innovation in prophylactic migraine therapy. The combination of Onabotulinumtoxin-A (OBTA) and mAbs appears to be an effective, but costly, therapeutic option for resistant cases. New classes of molecules like gepants and ditans seem to give exceptional results. In addition, new prophylactic drugs are emerging with several targets: the pituitary adenylate cyclase-activating polypeptide (PACAP), ion channels, several receptors coupled to G proteins, orexin, and glutamate. All these therapies will implement and improve migraine management, as well as personalized medicine for each patient.
科研通智能强力驱动
Strongly Powered by AbleSci AI