小RNA
神经炎症
发病机制
脊髓
痛觉过敏
癌症研究
医学
基因敲除
长非编码RNA
CXCL13型
癌症
癌症疼痛
伤害
神经科学
生物信息学
内科学
核糖核酸
生物
炎症
趋化因子
基因
遗传学
趋化因子受体
受体
作者
Junjie Chen,Cui’e Lu,Xiaodong Wang,Lin Wang,Jia Chen,Fuhai Ji
摘要
Bone cancer pain (BCP) is the most frequently observed chronic cancer pain, and its development remains largely unexplored. Dysregulation of non-coding RNAs greatly contributes to the pathogenesis of BCP. In the present study, we found a new long noncoding RNA (lncRNA), NONRATT009773.2, and investigated its role in the spinal cord of BCP rats. Our results showed that NONRATT009773.2 was significantly up-regulated in BCP model rats, whereas depletion of NONRATT009773.2 attenuated BCP. In contrast, overexpression of NONRATT009773.2 triggered pain-like symptoms in normal animals. Moreover, NONRATT009773.2 functioned as a microRNA (miRNA) sponge to absorb miR-708-5p and up-regulated miRNA downstream target CXCL13, which plays fundamental roles in the initiation and maintenance of neuroinflammation and hyperalgesia. Collectively, our current findings indicated that NONRATT009773.2 could be employed as a new therapeutic target for BCP.
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