医学
囊性纤维化
免疫学
慢性阻塞性肺病
发病机制
疾病
特发性肺纤维化
哮喘
PI3K/AKT/mTOR通路
呼吸系统
免疫系统
信号转导
肺
病理
内科学
生物
生物化学
作者
John A. Marwick,Kian Fan Chung,Ian M. Adcock
标识
DOI:10.1177/1753465809352792
摘要
Respiratory diseases such as chronic obstructive pulmonary disease [COPD], severe asthma, cystic fibrosis [CF] and idiopathic pulmonary fibrosis [IPF] are inadequately controlled by current therapies. The underlying molecular mechanisms and pathogenesis of these diseases remain unclear, making identification and validation of potential new therapeutic targets difficult. However, recent studies have identified the central signalling mediator PI3K as playing an integral role in the immune system including initiation and maintenance of inflammatory responses. Specifically, the relatively leukocyte-specific PI3Kγ and PI3Kδ isoforms are central to leukocyte function and can be targeted pharmacologically. Early to man studies using selective PI3K isoform inhibitors are required to determine whether they have a future in treating respiratory disease, particularly in controlling both innate and adaptive inflammatory responses as well as restoring glucocorticoid function and reducing tumorigenesis.
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