免疫学
螨
特应性皮炎
医学
屋尘螨
免疫系统
抗原
促炎细胞因子
流式细胞术
CD154
过敏
生物
炎症
CD40
过敏原
细胞毒性T细胞
植物
生物化学
体外
作者
Masako Inaba,Hiroko Fukushima,Monami Hara,Sho Hosaka,Satoshi Fujiyama,Kazushi Maruo,Toshifumi Nomura,Naoko Okiyama,Hidetoshi Takada
标识
DOI:10.1016/j.clim.2023.109649
摘要
The number of regulatory T cells (Tregs) and how they behave in the pathogenesis of atopic dermatitis (AD) are still controversial. We identified and quantified Tregs, mite-specific Tregs, and mite-specific effector T cells (Teffs) in patients with AD and healthy controls (HCs). We collected peripheral blood and analyzed the cells using flow cytometry after stimulation with mite antigens. Mite-specific Tregs and mite-specific Teffs were recognized by the expression of CD137 and CD154, respectively. Patients with AD had more Tregs than HCs; however, when focusing on a single antigen, the ratio of mite-specific Tregs/Teffs was lower in patients with AD than in HCs. Furthermore, the mite-specific Teffs in patients with AD were more likely to produce proinflammatory cytokines interleukin (IL)-4 and IL-13. This Teff-dominant imbalance is thought to be the cause of development of atopic status in patients with AD without immune tolerance.
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