CO2 cerebrovascular reactivity measured with CBF-MRI in older individuals: Association with cognition, physical function, amyloid, and tau proteins

痴呆 临床痴呆评级 蒙特利尔认知评估 内科学 认知 脑血流 心脏病学 医学 病态的 匹兹堡化合物B 认知障碍 血管性痴呆 认知功能衰退 心理学 疾病 精神科
作者
Sandeepa Sur,Zixuan Lin,Yang Li,Sevil Yaşar,Paul B. Rosenberg,Abhay Moghekar,Xirui Hou,Dengrong Jiang,Rita R. Kalyani,Kaisha Hazel,George Pottanat,Cuimei Xu,Jay J. Pillai,Peiying Liu,Marilyn Albert,Hanzhang Lu
出处
期刊:Journal of Cerebral Blood Flow and Metabolism [SAGE Publishing]
卷期号:44 (9): 1618-1628 被引量:3
标识
DOI:10.1177/0271678x241240582
摘要

Vascular pathology is the second leading cause of cognitive impairment and represents a major contributing factor in mixed dementia. However, biomarkers for vascular cognitive impairment and dementia (VCID) are under-developed. Here we aimed to investigate the potential role of CO2 Cerebrovascular Reactivity (CVR) measured with phase-contrast quantitative flow MRI in cognitive impairment and dementia. Forty-five (69 ± 7 years) impaired (37 mild-cognitive-impairment and 8 mild-dementia by syndromic diagnosis) and 22 cognitively-healthy-control (HC) participants were recruited and scanned on a 3 T MRI. Biomarkers of AD pathology were measured in cerebrospinal fluid. We found that CBF-CVR was lower (p = 0.027) in the impaired (mean±SE, 3.70 ± 0.15%/mmHg) relative to HC (4.28 ± 0.21%/mmHg). After adjusting for AD pathological markers (Aβ42/40, total tau, and Aβ42/p-tau181), higher CBF-CVR was associated with better cognitive performance, including Montreal Cognitive Assessment, MoCA (p = 0.001), composite cognitive score (p = 0.047), and language (p = 0.004). Higher CBF-CVR was also associated with better physical function, including gait-speed (p = 0.006) and time for five chair-stands (p = 0.049). CBF-CVR was additionally related to the Clinical-Dementia-Rating, CDR, including global CDR (p = 0.026) and CDR Sum-of-Boxes (p = 0.015). CBF-CVR was inversely associated with hemoglobin A1C level (p = 0.017). In summary, CBF-CVR measured with phase-contrast MRI shows associations with cognitive performance, physical function, and disease-severity, independent of AD pathological markers.
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