生物
病毒学
BK病毒
病毒
允许的
发病机制
宽容
人口
病毒复制
无症状的
肾
免疫学
遗传学
肾移植
内科学
医学
环境卫生
作者
Ilnaz Sahragard,Ramin Yaghobi,Ali Mohammadi,Afsoon Afshari,Maryam Pakfetrat,Mohammad Karimi,Mahmoud Reza Pourkarim
出处
期刊:Gene
[Elsevier]
日期:2024-03-01
卷期号:: 148376-148376
标识
DOI:10.1016/j.gene.2024.148376
摘要
The human BK Polyomavirus (BKPyV) is a DNA virus that is prevalent in 80 % of the population. Infection with this virus may begin in childhood, followed by asymptomatic persistence in the urinary tract. However, in immunocompromised individuals, especially kidney transplant recipients (KTRs), heightened replication of BKPyV can lead to severe complications. The genome of this virus is divided into three parts; the early and late region, and the non-coding control region (NCCR). Mutations in the NCCR can change the archetype strain to the rearranged strain, and NCCR rearrangements play a significant in virus pathogenesis. Interestingly, diverse types of NCCR block rearrangement result in significant differences in conversion potential and host cell viability in the infected cells. A correlation has been detected between increased viral replication potential and pathogenesis in BKPyV-infected KTRs with specific NCCR rearrangements. The objective of this review study was to examine the disease-causing and clinical consequences of variations in the NCCR in BKPyV-infected KTRs such as virus-associated nephropathy (BKPyVAN).
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