亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Effects of 1-oleate-2-palmitate-3-linoleate glycerol supplementation on the small intestinal development and gut microbial composition of neonatal mice

甘油 作文(语言) 食品科学 化学 肠道菌群 肠道菌群 生物化学 生物 细菌 哲学 语言学 遗传学
作者
Fang Wu,Yaqiong Liu,Ming Zhang,Xinlei Yuan,Tengteng Ji,Yutong Jin,Yixuan Li,Ran Wang,Yanling Hao,Bing Fang
出处
期刊:Food Research International [Elsevier BV]
卷期号:195: 114993-114993 被引量:1
标识
DOI:10.1016/j.foodres.2024.114993
摘要

Recent studies have shown that 1-oleo-2-palmito-3-linoleyl glycerol (OPL) is the most abundant triacylglycerol in human breast milk in China. Epidemiologic studies have shown that sn-2 palmitate improves the absorption of fatty acids and calcium in infants. However, there have been few studies of the specific mechanism by which OPL affects intestinal function. In the present study, we have characterized the effects of various levels of OPL supplementation on the development of the intestinal epithelium and the intestinal microbiota of neonatal mice. OPL supplementation increased the body masses and intestinal lengths of weaned mice and promoted defecation. These positive effects were related to the effect of OPL to promote the development of intestinal villi and crypts. OPL increased the expression of the intestinal stem cell markers Olfm4 and Sox9 in the jejunum and ileum, which promoted their differentiation into goblet cells and Paneth cells. It also promoted the integrity of the epithelial barrier by increasing the secretion of mucin 2 and lysozyme 1 and the expression of the tight junction proteins occludin, ZO1, claudin 2, and claudin 3. More importantly, we found that low dose-OPL promotes the transformation of the intestinal microbiota of neonatal mice to the mature state in 3-month-old mice, increases the proportion of Firmicutes, and reduces the proportion of Bacteroidota. The proportions of anaerobic genera of bacteria, such as Lachnospiraceae_NK4A136_group, Lachnoclostridium, Ligilactobacillus, and Bifidobacterium were higher, as were the key producers of short-chain fatty acids, such as Bacteroides and Blautia. OPL also increased the butyric acid content of the feces, which significantly correlated with the abundance of Lactobacillus. High-dose OPL tended to be more effective at promoting defecation and the development of the villi and crypts, but these effects did not significantly differ from those achieved using the lower dose. A low dose of OPL was more effective at increasing the butyric acid content and causing the maturation of microbes. In summary, the OPL supplementation of newborn mice promotes the establishment of the intestinal epithelial layer structure and barrier function, and also promotes the transformation of the intestinal microbiota to a mature state. This study lays a theoretical foundation for the inclusion of OPL in infant formula and provides a scientific basis for the development of intestinal health products.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
10秒前
AL完成签到,获得积分10
13秒前
灵感大王喵发布了新的文献求助200
14秒前
星星boy完成签到,获得积分10
15秒前
16秒前
科研小白发布了新的文献求助10
19秒前
23秒前
26秒前
26秒前
Marshall完成签到 ,获得积分10
27秒前
30秒前
30秒前
HCB1完成签到,获得积分20
30秒前
AL发布了新的文献求助10
30秒前
wyx完成签到 ,获得积分20
31秒前
董可以发布了新的文献求助10
32秒前
HCB1发布了新的文献求助10
33秒前
董可以完成签到,获得积分10
40秒前
传奇3应助科研通管家采纳,获得10
41秒前
小二郎应助科研通管家采纳,获得10
41秒前
领导范儿应助科研通管家采纳,获得10
41秒前
41秒前
Hello应助科研通管家采纳,获得10
41秒前
blue完成签到 ,获得积分10
43秒前
东风完成签到,获得积分10
44秒前
ceeray23发布了新的文献求助40
44秒前
万能图书馆应助HCB1采纳,获得10
44秒前
玩命的糖豆完成签到 ,获得积分10
51秒前
科研小白完成签到,获得积分10
52秒前
1分钟前
健康的大船完成签到 ,获得积分10
1分钟前
橙子完成签到 ,获得积分10
1分钟前
山城小丸完成签到,获得积分10
1分钟前
吴嘉俊发布了新的文献求助10
1分钟前
1分钟前
小丸子完成签到 ,获得积分10
1分钟前
彩色橘子完成签到 ,获得积分10
1分钟前
1分钟前
yyf251发布了新的文献求助10
1分钟前
阿金啊完成签到,获得积分10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532068
关于积分的说明 11256227
捐赠科研通 3270933
什么是DOI,文献DOI怎么找? 1805123
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216