Treatment of Hailey–Hailey disease with JAK inhibitors

Learning point for cliniciansJAK inhibitors may be a therapeutic option for Hailey-Hailey disease. Case reportA 48-year-old man presented to our clinic for treatment of recurrent flares of widespread erythematous erosive plaques underneath his thighs, axilla and neck since early adulthood.The patient reported that his mother, brother and sister also had a similar condition.He had a medical history of hypertension and was taking metoprolol succinate sustained-release tablets (47.5 mg daily), amlodipine besylate tablets (5 mg daily), and a Figure 1.(A) A biopsy consistent with Hailey-Hailey disease (scale bar, 250 µm).(B) Before treatment.(C) Response to upadacitinib 15 mg daily for the first 4 weeks, (D) followed by tofacitinib 5 mg daily for the remaining 20 weeks of the 24-week treatment.