Evaluation of Cilnidipine Loaded Selfmicroemulsifying Drug Delivery System (SMEDDS) by Quantification of Comparative Pharmacokinetic Parameters using validated LC-ESI-MS/MS Bioanalytical Method and Pharmacodynamic Assessment

Regardless of having desired therapeutic properties many of the recently approved drugs are removed from the developmental pipeline for their clinical use due to low solubility and permeability. Conventional dosage forms are found relatively unsuitable for achieving desired pharmacokinetic and pharmacodynamics profiles.Cilnidipine is 1,4 dihydropyridine derivative calcium channel blocker used for the treatment of hypertension.