氧化应激
炎症
活性氧
氧化铈
间充质干细胞
生物相容性
葡萄膜炎
材料科学
医学
化学
免疫学
细胞生物学
病理
氧化物
生物
生物化学
冶金
作者
Jiawei Zhao,Yingjie Wang,Yiquan Zhang,Xinyu Guo,Han Bao,Yong Tao
标识
DOI:10.1002/adhm.202402523
摘要
Abstract Posterior uveitis is a leading cause of vision impairment and blindness globally due to its detrimental effects on the choroid and retina. The condition is worsened by oxidative stress, which heightens inflammation and perpetuates a cycle of damage that current treatments only temporarily relieve. To address this, a novel treatment involving the in situ crystallization of ultrasmall cerium oxide nanoparticles (≈3 nm) on mesenchymal stem cell (MSC) extracellular vesicles (EVs) for the management of primed mycobacterial uveitis (PMU) is developed. This nanohybrid leverages the individual and synergistic effects of its components for a comprehensive therapeutic approach. The cerium oxide nanoparticles act as a nanozyme to reduce inflammation and scavenge excessive reactive oxygen species (ROS), while the MSC EVs, with their biocompatibility, modulate inflammatory cell infiltration and alleviate tissue damage. This synergistic system offers a promising new treatment strategy for ocular diseases characterized by oxidative stress and inflammation.
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