High-Throughput Experimentation in Discovery Chemistry: A Perspective on HTE Uses and Laboratory Setup

The acceleration of Design-Make-Test-Analyze (DMTA) cycles is a critically important objective across Discovery Chemistry organizations and efforts to impact these cycle times have led to the development and implementation of technologies such as high-throughput experimentation (HTE). The ability to run hundreds or thousands of reactions reliably and at the same time via HTE has transformed the way chemistry is executed. Herein, we describe how this technology can enable more efficient DMTA cycles in medicinal chemistry and how we approached building a state-of-the-art HTE group and laboratory at Janssen over the past 2 years. Our tactic in democratizing HTE within our Discovery Chemistry department is also described.