免疫系统
免疫
免疫失调
生物
疾病
免疫学
自身免疫性疾病
获得性免疫系统
人口
医学
抗体
环境卫生
病理
作者
Hua Wang,Hong Wu,Kaidi Li,Yiyu Wang,Renfang Huang,Yujie Du,Jin Xue,Qianru Zhang,Xian‐Bao Li,Baozhu Li
标识
DOI:10.1016/j.autrev.2022.103234
摘要
Nearly 20 years of studies have shown that fungi and the human immune system (non-specific immunity and specific immunity) and bacterial--fungal interactions maintain a balance that can't lead to diseases. Fungi--microorganism that lives in human intestine--may play an important role in human health and disease. Population studies and animal models in some diseases have found the changes in the diversity and composition of fungi. The dysregulation of the fungi can disrupt the normal "running" of the immune system and bacteria, which triggers the development of inflammatory diseases. The latest studies of fungi in inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis and type 1 diabetes mellitus were summarized. This review considers how the healthy host protect against the potential harm of intestinal fungi through the immune system and how fungal dysregulation alters host immunity.
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