Early Prediction Model of Radiation-Induced Xerostomia Based on Radiomics during Radiotherapy for Nasopharyngeal Carcinoma

医学 鼻咽癌 无线电技术 放射治疗 肿瘤科 放射科 内科学
作者
Minyu Feng,Xiaohua Du,Y. Yin,L. Yan,H. Wang,Q. Yin,L. Li,M. Fan,X. Lai,Y. Huang,J. Ren,J. Lang
出处
期刊:International Journal of Radiation Oncology Biology Physics [Elsevier]
卷期号:114 (3): S48-S48
标识
DOI:10.1016/j.ijrobp.2022.07.420
摘要

Purpose/Objective(s)

Radiation-induced xerostomia remains one of common side effects for radiotherapy (RT) of nasopharyngeal carcinoma (NPC) and severely affects the quality of life. Early prediction of xerostomia is extremely important, but few studies mention it. We aim to build the early prediction model of xerostomia based on radiomics during RT by artificial intelligence for NPC patients.

Materials/Methods

Seventy-five pathologically confirmed squamous NPC patients were prospectively enrolled in our institution. All patients received a total radiation dose of 66 to 70Gy in 33 fractions at 5 fractions per week using Image-guided intensity modulated radiotherapy (IGRT). The patients received 3-5 cycles of cisplatin-based chemotherapy. MR images with T2-weighted (T2WI), contrast-enhanced T1-weighted (CE-T1WI) and diffusion-weighted imaging (DWI) (b = 0, 500, 800 s/mm2) were acquired on 3.0T MRI. RTOG criteria was used to evaluate xerostomia at 3 months after the completion of radiation. Delivered radiation dose of bilateral parotid and submandibular glands, MR images were collected at pre-RT, 5th, 15th fractions and immediately post-RT, respectively. Bilateral parotid and submandibular glands were delineated as the regions of interest (ROI) on CE-T1WI, T2WI, and DWI. We extracted a variety of features from all the images, and selected the optimal features combination by variance analysis. We built the prediction model by support vector machine (SVM). Receiver-operating characteristic (ROC) curve was used to evaluate predictive performance.

Results

The average age was 44.88 years (23-79 years). 24 were female and 51 were male. The mean ADC values of parotid and submandibular glands increased gradually during radiotherapy. Furthermore, the mean ADC values of salivary glands began to increase at 5th fractions with minimal volume change. For xerostomia, 34 patients with G3-5 were categorized as toxicity cases, and 41 patients with G0-2 were classified as non-toxicity cases. Based on radiomics, clinical characteristics (sex, age, 8th TNM staging) and radiation dose, we built 15 prediction models. Among them, the best prediction model consists of radiation dose, clinical parameters and ΔRF (the delta-radiomics features from pre-RT to 5th fractions) which includes 6 ipsilateral parotid features, 8 contralateral parotid features, 7 ipsilateral submandibular features, and 7 contralateral submandibular features. The area under ROC curve is 0.7641, with a precision of 0.7444, a sensitivity of 0.7238, and a specificity of 0.8424.

Conclusion

Early prediction model including delta-radiomics, radiation dose, and clinical parameters exhibits superior sensitivity and specificity. This is an effective model for predicting xerostomia during the early stage of RT, and the clinicians could use it to adjust the treatment strategy and reduce the damage to salivary glands.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
缓慢的誉完成签到,获得积分10
1秒前
NexusExplorer应助研友_pnxEqZ采纳,获得10
3秒前
啦啦啦完成签到 ,获得积分10
9秒前
rafa完成签到 ,获得积分10
10秒前
LWJ完成签到 ,获得积分10
12秒前
加油完成签到 ,获得积分10
13秒前
14秒前
DD完成签到,获得积分10
16秒前
16秒前
liu完成签到 ,获得积分10
16秒前
17秒前
AUGKING27完成签到 ,获得积分10
17秒前
研友_pnxEqZ发布了新的文献求助10
17秒前
研友_841oDL完成签到,获得积分10
18秒前
害羞的书芹完成签到,获得积分10
22秒前
25秒前
隐形白开水完成签到,获得积分10
25秒前
自然水杯发布了新的文献求助10
25秒前
崇林同学发布了新的文献求助20
28秒前
勤劳半青完成签到,获得积分10
29秒前
stronging发布了新的文献求助10
30秒前
zhangyidian完成签到,获得积分10
32秒前
妙脆角完成签到 ,获得积分10
33秒前
Sylvia完成签到 ,获得积分10
34秒前
爱听歌的糖豆完成签到,获得积分10
34秒前
吴壮完成签到,获得积分0
35秒前
med1640完成签到,获得积分10
35秒前
无辜念文完成签到,获得积分10
38秒前
wbx完成签到,获得积分10
40秒前
轩辕白竹完成签到,获得积分10
40秒前
李爱国应助科研通管家采纳,获得10
42秒前
今后应助科研通管家采纳,获得10
42秒前
无花果应助科研通管家采纳,获得10
43秒前
脑洞疼应助科研通管家采纳,获得10
43秒前
隐形曼青应助科研通管家采纳,获得10
43秒前
思源应助科研通管家采纳,获得10
43秒前
43秒前
43秒前
正直老九完成签到 ,获得积分10
45秒前
suxin发布了新的文献求助10
45秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Handbook of Qualitative Cross-Cultural Research Methods 600
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3139737
求助须知:如何正确求助?哪些是违规求助? 2790662
关于积分的说明 7796051
捐赠科研通 2447104
什么是DOI,文献DOI怎么找? 1301563
科研通“疑难数据库(出版商)”最低求助积分说明 626300
版权声明 601176