医学
优势比
胚胎移植
置信区间
怀孕
妇科
流产
激素替代疗法(女性对男性)
激素拮抗剂
产科
内科学
激素
生物
内分泌系统
遗传学
睾酮(贴片)
作者
Fazilet Kübra Boynukalın,Remzi Abalı,Meral Gültomruk,Berfu Demir,Zalihe Yarkıner,G. Karlikaya,Mustafa Bahçeci,Dominique de Ziegler
出处
期刊:F&S reports
[Elsevier]
日期:2023-06-01
卷期号:4 (2): 165-172
被引量:1
标识
DOI:10.1016/j.xfre.2022.11.002
摘要
To compare the ongoing pregnancy rates (OPRs) for subcutaneous progesterone (SC-P) to intramuscular progesterone (IM-P) in hormone replacement therapy used in frozen embryo transfer (FET) cycles.Prospective nonrandomized cohort study.Private fertility clinic.The study enrolled 224 patients scheduled for hormone replacement therapy (HRT)-FET cycles with SC-P (n = 133) or IM-P (n = 91). The route of P administration was decided according to the patient's preference and accessibility to the hospital. In the first FET cycle of a freeze-all cycle using single blastocyst transfers, a woman aged ≤35 was included.Ongoing pregnancy (OP).The demographic, cycle, and embryologic characteristics were similar between groups. The clinical pregnancy rates (86/133[64.7%] vs. 57/91[62.6%]); miscarriage rates (21/86 [24.4%] vs. 10/57 [17.5%]), and OPR (65/133 [48.9%] vs. 47/91 [51.6%]) were comparable between the SC-P and IM-P groups. Binary logistic regression for OP as the dependent factor revealed that blastocyst morphology was found to be a significant independent prognosticator (for poor quality embryos adjusted odds ratio, 0.11; 95% confidence interval, 0.029-0.427) and progesterone route (SC-P vs. IM-P) was an insignificant prognosticator (adjusted odds ratio, 0.694; 95% confidence interval, 0.354-1.358).The OPR for SC-P administration was similar to that for IM-P in HRT-FET cycles. The effect of ET-day P levels may vary regarding the administration route. Randomized controlled trials comparing different P administration routes are needed, and large-scale prospective trials are warranted to evaluate the ET-day P levels on pregnancy outcome.
科研通智能强力驱动
Strongly Powered by AbleSci AI