Efforts and Strategies for the Syntheses of Clavine‐Type Ergot Alkaloid Aurantioclavine

Abstract Aurantioclavine, isolated by Kozlovskii from Penicillium aurantiovirens , is a unique member of the 3,4‐disubstituted indole alkaloids distinguished by an azepino[5,4,3‐ cd ]indole. As an essential intermediate in the biosynthesis of the complex polycyclic alkaloids of the fungal communesin, it has attracted considerable attention as a synthetic target. The development of various synthetic strategies for their application in total synthesis has been described. An overview focused on the synthesis of aurantioclavine from its first synthesis to the most recent one is present.