Metal‐catalyzed Radical Trifluoromethylthiolation of Aryl Boronic Acids in the Aqueous Phase

Abstract We successfully developed an efficient and environment‐friendly reaction with aryl boronic acids to obtain a wide range of trifluoromethylthiolated molecules in satisfactory yields. Investigations of the reaction mechanism indicated that this transformation proceeds via a free radical pathway. Compared to the previously reported radical strategies, the reagent 2 d was thermally stable, easily synthesized, and a scalable trifluoromethylthiolating reagent. This method will enable organic chemists to easily synthesize molecules bearing the SCF 3 group under conditions that are compatible with various other functional groups.