Cuffless blood pressure estimation using chaotic features of photoplethysmograms and parallel convolutional neural network

As a nonlinear framework in dynamical system analysis, chaotic approaches are mainly applied to evolve the complexity of biological systems. Due to the chaotic nature of the cardiovascular systems, the nonlinear features can intuitively provide a reliable framework in blood pressure (BP) estimation. Cuffless BP estimation is usually carried out by establishing deep neural network models estimating the BP values through machine-learned features of photoplethysmogram (PPG) signals.In this study, a novel parallel deep architecture is proposed to handle the machine-learned and chaotic features of PPG signals in estimating the actual BP values. The chaotic handcrafted features were the signal properties associated with the Poincare sections in the phase space and the recurrence plot-based measures called recurrence quantification analysis (RQA). Moreover, the measures quantifying the nonlinear properties of the temporal sequences such as correlation dimension, fractal dimension, Lyapunov exponent, and entropy-based quantities were also employed. The parallel architecture not only embedded the chaotic nature of PPG signals but also provided a facility to include the pseudo-periodic variations of PPGs by utilizing a concatenating layer.Our framework was examined on the public dataset, namely, Multi-Parameter Intelligent in Intensive Care II contained the recording of PPG, ECG and arterial blood pressure. The performance of the employed handcrafted features in distinguishing between the levels of BP values was investigated based on Spearman's statistics. In addition, our proposed scheme is evaluated in terms of Pearson's correlation coefficient (R), root mean square error (RMSE), and mean absolute error (MAE). The best performance was achieved when the employed handcrafted features accompanied by PPG sequences were applied to the parallel deep network. In particular, the values of R, RMSE, and MAE were obtained 0.9529, 2.76 mmHg, and 1.73 mmHg for diastolic BP, and 0.9444, 6.18 mmHg, and 3.8 mmHg for systolic BP, respectively. Moreover, based on the requirements of the standards set by the British Hypertension Society (BHS), the proposed scheme achieved a grade of A.Our proposed scheme outperformed the state-of-the-art BP estimation methods. In addition, the results confirmed that the concatenation of the PPG-related machine-learned and nonlinear handcrafted features can be properly applied in continuous BP monitoring.