Intraoperative Fraction of Inspired Oxygen and Lung Injury in Coronary Artery Bypass Grafting: Study Protocol for a Randomised Controlled Trial

医学 吸入氧分数 充氧 重症监护室 麻醉 机械通风 脉搏血氧仪 心脏外科 外科 重症监护医学
作者
Kaicheng Song,Sheng Wang,Jian Han,Luyang Jiang,Jianguo Xu,Ozan Akça,Kandis Adkins,Heidi M. Koenig,Mark S. Slaughter,Sean P. Clifford,Yuguang Huang,Jiapeng Huang
出处
期刊:Turkish journal of anaesthesiology and reanimation 卷期号:51 (2): 112-120
标识
DOI:10.5152/tjar.2023.22974
摘要

Postoperative pulmonary complications are a series of disorders that can contribute to respiratory distress and prolonged mechanical ventilation postoperatively. We hypothesise that a liberal oxygenation strategy during cardiac surgery leads to a higher incidence of postoperative pulmonary complications than a restrictive oxygenation strategy.This study is a prospective, observer-blinded, centrally randomised and controlled, international multicentre clinical trial.After obtaining a written informed consent, 200 adult patients undergoing coronary artery bypass grafting will be enrolled and randomised to receive either restrictive or liberal oxygenation perioperatively. The liberal oxygenation group will receive 1.0 fraction of inspired oxygen throughout the intraoperative period, including during cardiopulmonary bypass. The restrictive oxygenation group will receive the lowest fraction of inspired oxygen required to maintain arterial partial pressure of oxygen between 100 and 150 mmHg during cardiopulmonary bypass and a pulse oximetry reading of 95% or greater intraoperatively, but no less than 0.3 and not higher than 0.80 (other than induction and when the oxygenation goals cannot be reached). When patients are transferred to the intensive care unit, all patients will receive an initial fraction of inspired oxygen of 0.5, and then fraction of inspired oxygen will be titrated to maintain a pulse oximetry reading of 95% or greater until extubation. The lowest postoperative arterial partial pressure of oxygen/fraction of inspired oxygen within 48 hours of intensive care unit admission will be the primary outcome. Postoperative pulmonary complications, length of mechanical ventilation, intensive care unit stay, hospital stay, and 7-day mortality after cardiac surgery will be analysed as secondary outcomes.This is one of the first randomised controlled observer-blinded trials that prospectively evaluates the influence of higher inspired oxygen fractions on early postoperative respiratory and oxygenation outcomes in cardiac surgery patients using cardiopulmonary bypass.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
艾迪富富完成签到,获得积分10
刚刚
积极幻桃应助白榆采纳,获得10
1秒前
量子星尘发布了新的文献求助10
1秒前
小坤同学发布了新的文献求助10
2秒前
3秒前
紫津发布了新的文献求助10
3秒前
3秒前
科研通AI5应助成就的翠琴采纳,获得10
5秒前
6秒前
zzz发布了新的文献求助10
6秒前
迪宝有好运完成签到,获得积分20
7秒前
7秒前
yiyiy完成签到,获得积分10
8秒前
淡然的铭发布了新的文献求助10
8秒前
8秒前
斯文败类应助超帅凡阳采纳,获得10
10秒前
10秒前
Owen应助四月采纳,获得20
10秒前
Quinna发布了新的文献求助10
11秒前
在水一方应助温柔映阳采纳,获得200
11秒前
12秒前
眯眯眼的芷天完成签到,获得积分10
12秒前
ZJH完成签到,获得积分20
12秒前
13秒前
思源应助Keyl采纳,获得10
14秒前
万能图书馆应助故晨采纳,获得10
15秒前
15秒前
爆米花应助excellent采纳,获得10
15秒前
17秒前
18秒前
彬彬完成签到,获得积分10
18秒前
blank发布了新的文献求助10
19秒前
19秒前
20秒前
沈彬彬发布了新的文献求助10
21秒前
Rondab应助松松采纳,获得10
21秒前
akihi关注了科研通微信公众号
21秒前
18幺八发布了新的文献求助10
21秒前
22秒前
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Economic Geography and Public Policy 900
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988786
求助须知:如何正确求助?哪些是违规求助? 3531116
关于积分的说明 11252493
捐赠科研通 3269766
什么是DOI,文献DOI怎么找? 1804771
邀请新用户注册赠送积分活动 881870
科研通“疑难数据库(出版商)”最低求助积分说明 809021