自愈水凝胶
伤口愈合
生物相容性
生物医学工程
体内
活性氧
壳聚糖
再生(生物学)
荧光
化学
材料科学
生物物理学
外科
细胞生物学
医学
生物化学
高分子化学
生物
物理
生物技术
冶金
量子力学
作者
Yuange Zong,Beige Zong,Ruyan Zha,Yi Zhang,Xianghong Li,Yanying Wang,Huaifang Fang,Wing‐Leung Wong,Yuange Zong
标识
DOI:10.1002/adhm.202300431
摘要
Abstract The design and synthesis of multifunctional chitosan hydrogels based on polymerized ionic liquid and a near‐infrared (NIR) fluorescent probe (PIL‐CS) is a promising strategy, which not only prevents the transition from acute to chronic wounds, but also provides prompt measures regarding microenvironmental alterations in chronic wounds. PIL‐CS hydrogel can real‐time visualize wound pH through in vivo NIR fluorescent imaging and also feature the pH‐responsive sustained drug release, such as antioxidant, to eliminate reactive oxygen species (ROS) and to boost diabetic wound healing. PIL‐CS hydrogel is specific, sensitive, stable, and reversible in response to pH changes at the wound site. It, therefore, enables real‐time monitoring for a dynamic pH change in the microenvironment of irregular wounds. PIL‐CS hydrogel is also designed to possess many merits including high water containment and swelling rate, good biocompatibility, electrical conductivity, antifreeze, tissue adhesion, hemostatic performance, and efficient antibacterial activity against MRSA. In vivo studies showed that PIL‐CS hydrogel provided fast diabetic wound healing support, promoted vascular endothelial growth factor (VEGF) production, and reduced ROS and tumor necrosis factor (TNF‐ α) generation. The results support that the hydrogels coupled with NIR fluorescent probes can be an excellent diabetic wound dressing for enhancing and real‐time monitoring skin restoration and regeneration.
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