亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

HnRNPK is involved in stress-induced depression-like behavior via ERK-BDNF pathway in mice

MAPK/ERK通路 神经科学 海马结构 神经营养因子 激酶 信号转导 海马体 磷酸化 脑源性神经营养因子 生物 细胞生物学 心理学 遗传学 受体
作者
Lv-Ping Zhuang,Weiqi Gao,Liu-Lv Fang,Guirong Zeng,Qinyong Ye,Xiaoman Dai,Jing Zhang,Xiaochun Chen
出处
期刊:Neurochemistry International [Elsevier]
卷期号:169: 105589-105589 被引量:2
标识
DOI:10.1016/j.neuint.2023.105589
摘要

As a ubiquitous RNA-binding protein, heterogeneous nuclear ribonucleoprotein K (hnRNPK) interacts with numerous nucleic acids and proteins and is involved in various cellular functions. Available literature indicates that it can regulate dendritic spine density through the extracellular signal-regulating kinase (ERK) - brain-derived neurotrophic factor (BDNF) pathway, which is crucial to retain the synaptic plasticity in patients with major depressive disorder (MDD) and mouse depression models. However, ERK upstream regulatory kinase has not been fully elucidated. Furthermore, it remains unexplored whether hnRNPK may impact the depressive condition via the ERK pathway. The present study addressed this issue by integrating approaches of genetics, molecular biology, behavioral testing. We found that hnRNPK in the brain was mainly distributed in the hippocampal neurons; that it was significantly downregulated in mice that displayed stress-induced depression-like behaviors; and that the level of hnRNPK markedly decreased in MDD patients from the GEO database. Further in vivo and in vitro analyses revealed that the changes in the expressions of BDNF and PSD95 and in the phosphorylation of ERK (Thr202/Tyr204) paralleled the variation of hnRNPK levels in the ventral hippocampal neurons in mice with depression-like behaviors. Finally, esketamine treatment significantly increased the level of hnRNPK in mice. These findings evidence that hnRNPK involved in the pathogenesis of depression via the ERK-BDNF pathway, pinpointing hnRNPK as a potential therapeutic target in treating MDD patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
良辰应助科研通管家采纳,获得10
5秒前
9秒前
甜蜜发带完成签到 ,获得积分10
29秒前
59秒前
执着夏山发布了新的文献求助10
1分钟前
1分钟前
一墨完成签到,获得积分10
1分钟前
1分钟前
清爽夜雪完成签到,获得积分10
1分钟前
从容栾发布了新的文献求助10
1分钟前
科研搬运工完成签到,获得积分10
1分钟前
无花果应助Demi_Ming采纳,获得10
1分钟前
1分钟前
脑洞疼应助科研通管家采纳,获得10
2分钟前
良辰应助科研通管家采纳,获得10
2分钟前
2分钟前
Demi_Ming发布了新的文献求助10
2分钟前
2分钟前
2分钟前
2分钟前
执着夏山发布了新的文献求助10
2分钟前
3分钟前
3分钟前
3分钟前
3分钟前
甜梨完成签到,获得积分10
4分钟前
4分钟前
4分钟前
俭朴的大有完成签到,获得积分10
4分钟前
TXZ06完成签到,获得积分10
4分钟前
4分钟前
5分钟前
执着夏山发布了新的文献求助100
5分钟前
5分钟前
CipherSage应助科研通管家采纳,获得10
6分钟前
Z小姐完成签到 ,获得积分10
6分钟前
梨梨lilili完成签到,获得积分20
6分钟前
JamesPei应助cacaldon采纳,获得10
6分钟前
研友_VZG7GZ应助梨梨lilili采纳,获得30
6分钟前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
叶剑英与华南分局档案史料 500
Foreign Policy of the French Second Empire: A Bibliography 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3146739
求助须知:如何正确求助?哪些是违规求助? 2798045
关于积分的说明 7826588
捐赠科研通 2454566
什么是DOI,文献DOI怎么找? 1306391
科研通“疑难数据库(出版商)”最低求助积分说明 627708
版权声明 601527