立体中心
联氨(抗抑郁剂)
催化作用
镍
化学
硼烷
对映选择合成
组合化学
立体化学
有机化学
硼
生物化学
作者
Chuanyong Wang,Qingliang Yang,Yuan‐Hao Dai,Jianqi Xiong,Yu Zheng,Wei‐Liang Duan
标识
DOI:10.1002/anie.202313112
摘要
Catalytic asymmetric methods for the synthesis of synthetically versatile P-stereogenic building blocks offer an efficient and practical approach for the diversity-oriented preparation of P-chiral phosphorus compounds. Herein, we report the first nickel-catalyzed synthesis of P-stereogenic secondary aminophosphine-boranes by the asymmetric addition of primary phosphines to azo compounds. We further demonstrate that the P-H and P-N bonds on these phosphanyl hydrazine building blocks can be reacted sequentially and stereospecifically to access various P-stereogenic compounds with structural diversity.
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