Cu‐Catalyzed Cross‐Coupling Reactions of Enamines and Terminal Alkynes: Access of Propargylamines as Neurodegenerative Disorder Agents

Abstract Reactions between enamine analogues and terminal alkynes were explored. Copper(I) complex of 1,10‐phenanthroline catalyzed these reactions to generate a diastereoselective propargylamines via C−C bond formation. In the presence of Zn 2+ , the chiral propargylamines converted into the β ‐allenoates with an excellent yield and enantioselectivity achieved up to 99 %. Models of synthesized propargylamines were used for molecular docking and dynamic simulations, which indicate that this class of molecules shows promise for anti‐neurodegenerative activity.