Is the shock index correlated with blood loss? An experimental study on a controlled hemorrhagic shock model in piglets

血流动力学 医学 失血性休克 血压 休克(循环) 冲程容积 麻醉 平均动脉压 心脏病学 血容量 脉冲压力 心脏指数 冲程(发动机) 相关性 内科学 心输出量 心率 数学 几何学 机械工程 工程类
作者
Thomas W. Sanchez,Fabien Coisy,Laura Grau-Mercier,T. Desmettre,Florian Ajavon,Pierre-Géraud Claret,Thibaut Markarian,Xavier Bobbia
出处
期刊:American Journal of Emergency Medicine [Elsevier]
卷期号:75: 59-64
标识
DOI:10.1016/j.ajem.2023.10.026
摘要

The quantification of blood loss in a severe trauma patient allows prognostic quantification and the engagement of adapted therapeutic means. The Advanced Trauma Life Support classification of hemorrhagic shock, based in part on hemodynamic parameters, could be improved. The search for reproducible and non-invasive parameters closely correlated with blood depletion is a necessity. An experimental model of controlled hemorrhagic shock allowed us to obtain hemodynamic and echocardiographic measurements during controlled blood spoliation. The primary aim was to demonstrate the correlation between the Shock Index (SI) and blood depletion volume (BDV) during the hemorrhagic phase of an experimental model of controlled hemorrhagic shock in piglets. The secondary aim was to study the correlations between blood pressure (BP) values and BDV, SI and cardiac output (CO), and pulse pressure (PP) and stroke volume during the same phase.We analyzed data from 66 anesthetized and ventilated piglets that underwent blood spoliation at 2 mL.kg-1.min-1 until a mean arterial pressure (MAP) of 40 mmHg was achieved. During this bleeding phase, hemodynamic and echocardiographic measurements were performed regularly.The correlation coefficient between the SI and BDV was 0.70 (CI 95%, [0.64; 0.75]; p < 0.01), whereas between MAP and BDV, the correlation coefficient was -0.47 (CI 95%, [-0.55; -0.38]; p < 0.01). Correlation coefficient between SI and CO and between PP and stroke volume were - 0.45 (CI 95%, [-0.53; -0.37], p < 0.01) and 0.62 (CI 95%, [0.56; 0.67]; p < 0.01), respectively.In a controlled hemorrhagic shock model in piglets, the correlation between SI and BDV seemed strong.

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