Deep Learning Performance of Ultra-Widefield Fundus Imaging for Screening Retinal Lesions in Rural Locales

医学 眼底(子宫) 眼科 视网膜 黄斑变性 后极 验光服务
作者
Tingxin Cui,Duoru Lin,Shanshan Yu,Xinyu Zhao,Zhenzhe Lin,Lanqin Zhao,Fabao Xu,Dongyuan Yun,Jianyu Pang,Ruiyang Li,Liqiong Xie,Pengzhi Zhu,Yuzhe Huang,Hongxin Huang,Changming Hu,Wenyong Huang,Xiaoling Liang,Haotian Lin
出处
期刊:JAMA Ophthalmology [American Medical Association]
卷期号:141 (11): 1045-1045 被引量:4
标识
DOI:10.1001/jamaophthalmol.2023.4650
摘要

Retinal diseases are the leading cause of irreversible blindness worldwide, and timely detection contributes to prevention of permanent vision loss, especially for patients in rural areas with limited medical resources. Deep learning systems (DLSs) based on fundus images with a 45° field of view have been extensively applied in population screening, while the feasibility of using ultra-widefield (UWF) fundus image-based DLSs to detect retinal lesions in patients in rural areas warrants exploration.To explore the performance of a DLS for multiple retinal lesion screening using UWF fundus images from patients in rural areas.In this diagnostic study, a previously developed DLS based on UWF fundus images was used to screen for 5 retinal lesions (retinal exudates or drusen, glaucomatous optic neuropathy, retinal hemorrhage, lattice degeneration or retinal breaks, and retinal detachment) in 24 villages of Yangxi County, China, between November 17, 2020, and March 30, 2021.The captured images were analyzed by the DLS and ophthalmologists.The performance of the DLS in rural screening was compared with that of the internal validation in the previous model development stage. The image quality, lesion proportion, and complexity of lesion composition were compared between the model development stage and the rural screening stage.A total of 6222 eyes in 3149 participants (1685 women [53.5%]; mean [SD] age, 70.9 [9.1] years) were screened. The DLS achieved a mean (SD) area under the receiver operating characteristic curve (AUC) of 0.918 (0.021) (95% CI, 0.892-0.944) for detecting 5 retinal lesions in the entire data set when applied for patients in rural areas, which was lower than that reported at the model development stage (AUC, 0.998 [0.002] [95% CI, 0.995-1.000]; P < .001). Compared with the fundus images in the model development stage, the fundus images in this rural screening study had an increased frequency of poor quality (13.8% [860 of 6222] vs 0%), increased variation in lesion proportions (0.1% [6 of 6222]-36.5% [2271 of 6222] vs 14.0% [2793 of 19 891]-21.3% [3433 of 16 138]), and an increased complexity of lesion composition.This diagnostic study suggests that the DLS exhibited excellent performance using UWF fundus images as a screening tool for 5 retinal lesions in patients in a rural setting. However, poor image quality, diverse lesion proportions, and a complex set of lesions may have reduced the performance of the DLS; these factors in targeted screening scenarios should be taken into consideration in the model development stage to ensure good performance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
gby2018关注了科研通微信公众号
刚刚
刚刚
大模型应助樊书南采纳,获得10
1秒前
隐形曼青应助虚心的问丝采纳,获得10
2秒前
2秒前
3秒前
4秒前
chuan完成签到,获得积分10
5秒前
KoitoYuu发布了新的文献求助10
5秒前
22yh应助葛顺采纳,获得10
6秒前
6秒前
852应助看不懂采纳,获得10
7秒前
彭于晏应助朴素易梦采纳,获得30
8秒前
8秒前
lqh0211完成签到,获得积分10
8秒前
Francis_应助自觉的乌龟采纳,获得10
9秒前
9秒前
慕青应助su采纳,获得10
9秒前
10秒前
深情安青应助和道一文字采纳,获得10
11秒前
奇妙淞发布了新的文献求助10
12秒前
哎健身完成签到,获得积分10
12秒前
EricFan发布了新的文献求助10
13秒前
13秒前
李昕123发布了新的文献求助30
15秒前
汉堡包应助YHF2采纳,获得10
15秒前
阿钟发布了新的文献求助10
16秒前
冯冯发布了新的文献求助10
16秒前
17秒前
17秒前
陈哥完成签到 ,获得积分10
18秒前
19秒前
生活的狗完成签到,获得积分10
21秒前
22秒前
EricFan完成签到,获得积分10
23秒前
深情不弱发布了新的文献求助10
23秒前
aa发布了新的文献求助10
24秒前
andrele应助哎健身采纳,获得10
24秒前
小二郎发布了新的文献求助10
26秒前
26秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
《粉体与多孔固体材料的吸附原理、方法及应用》(需要中文翻译版,化学工业出版社,陈建,周力,王奋英等译) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3084785
求助须知:如何正确求助?哪些是违规求助? 2737877
关于积分的说明 7547149
捐赠科研通 2387454
什么是DOI,文献DOI怎么找? 1265984
科研通“疑难数据库(出版商)”最低求助积分说明 613207
版权声明 598429